GNF351 Inhibitor

Name: GNF351 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754914
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754914

GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNF351, Inhibitor

Full Product Name

GNF351

Product Gene Name

GNF351, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

411.50

Solubility

DMSO: 124mg/mL (301.34mM)
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C24H25N7

SMILES

CC(C)n1cnc2c(NCCc3c[nH]c4ccccc34)nc(nc12)-c1cncc(C)c1

CAS Number

1227634-69-6

Target & IC50

aryl hydrocarbon receptor: ic50 62nM

In Vitro

After treating proliferating monolayer cultures of human keratinocytes, GNF351 (500nM, 48 hours) obviously decreases the percentage of Ki67-positive cells and cell number.

Product Categories/Family for GNF351, inhibitor

Immunology/Inflammation

Product References and Citations for GNF351, inhibitor

van den Bogaard EH, et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.
van den Bogaard EH,et al. Genetic and pharmacological analysis identifies a physiological role for the AHR in epidermal differentiation. J Invest Dermatol. 2015 May;135(5):1320-1328.

Other Notes

Small volumes of GNF351, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNF351 purchase

MBS5754914 is an inhibitor targeting GNF351.