GSK2033 Inhibitor

Name: GSK2033 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754924
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754924

GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRalpha or LXRbeta, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK2033, Inhibitor

Full Product Name

GSK2033

Product Gene Name

GSK2033, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

591.66

Solubility

DMSO: 30mg/mL (50.70mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C29H28F3NO5S2

SMILES

O=S(C1=C(C)C=C(C)C=C1C)(N(CC2=CC=C(C3=CC=CC(S(=O)(C)=O)=C3)C=C2)CC4=CC=C(C(F)(F)F)O4)=O

CAS Number

1221277-90-2

Target & IC50

LXRalpha: ic50 7 (pic50)
LXRbeta: ic50 7.4 (pic50)

In Vitro

GSK2033 (one month) treatment, does not have obviously effects on hepatic triglyceride levels. GSK2033 treatment,also have no effects on plasma triglyceride levels[2].

Product Categories/Family for GSK2033, inhibitor

Liver X Receptor; Others

Product References and Citations for GSK2033, inhibitor

Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6.
Zuercher WJ, et al. Discovery of tertiary sulfonamides as potent liver X receptor antagonists. J Med Chem. 2010 Apr 22;53(8):3412-6.
Griffett K, et al. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.
Griffett K, et al. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. Biochem Biophys Res Commun. 2016 Oct 21;479(3):424-428.

Other Notes

Small volumes of GSK2033, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK2033 purchase

MBS5754924 is an inhibitor targeting GSK2033.