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Nemiralisib Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754927

MBS5754927 is an inhibitor targeting Nemiralisib. Nemiralisib is a potent and highly selective inhibitor of PI3Kdelta (pKi: 9.9). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nemiralisib, Inhibitor
Full Product Name
Nemiralisib
Product Synonym Names
GSK2269557 (free base)
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
440.54
Solubility
DMSO: 31mg/mL (70.37mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C26H28N6O
SMILES
CC(N1CCN(CC2=CN=C(C3=CC(C4=CC=CC5=C4C=CN5)=CC6=C3C=NN6)O2)CC1)C
CAS Number
1254036-71-9
Target & IC50
PI3Kdelta: ic50 9.9 (pki)
PI3Kgamma: ic50 5.2 (pic50)
PI3Kalpha: ic50 5.3 (pic50)
PI3Kbeta: ic50 5.8 (pic50)
In Vitro
Nemiralisib free base is active in a disease-relevant brown norway rat acute OVA model of Type 2 helper T-cells (Th2)-driven lung inflammation. Pharmacokinetic data from Sprague Dawley male rats are obtained to assess the suitability of the series for inhaled delivery clearance data in rat microsomes and subsequently in vivo. Compounds (e.g., Nemiralisib) are administered by the oral or intravenous routes, at a dose level of 3 and 1mg/kg respectively (n=2 rats/route)[1].

Product Categories/Family for Nemiralisib, inhibitor

PI3K/Akt/mTOR signaling; PI3K

Structure of Nemiralisib, inhibitor

Nemiralisib Inhibitor – Cat# MBS5754927

Product References and Citations for Nemiralisib, inhibitor

Down K et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase delta for the treatment,of Respiratory Disease. J Med Chem. 2015 Sep 24;58(18):7381-99.
Down K et al. Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase delta for the treatment,of Respiratory Disease. J Med Chem. 2015 Sep 24;58(18):7381-99.

Other Notes

Small volumes of Nemiralisib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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