GSK3145095 Inhibitor

Name: GSK3145095 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754932
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754932

GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5nM, with potential immunomodulatory activities and antineoplastic. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK3145095, Inhibitor

Full Product Name

GSK3145095

Product Gene Name

GSK3145095, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

397.38

Solubility

DMSO: 245mg/ml (616.54mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H17F2N5O2

SMILES

FC1=CC2=C(NC(=O)[C@H](CC2)NC(=O)C2=NNC(CC3=CC=CC=C3)=N2)C(F)=C1

CAS Number

1622849-43-7

Target & IC50

RIP1
RIP1 kinase: ic50 6.3nM

Product Categories/Family for GSK3145095, inhibitor

Apoptosis; TNF

Product References and Citations for GSK3145095, inhibitor

Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the treatment,of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862.

Other Notes

Small volumes of GSK3145095, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK3145095 purchase

MBS5754932 is an inhibitor targeting GSK3145095.