GW843682X Inhibitor

Name: GW843682X Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754942
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754942

GW843682X is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s: 2.2nM and 9.1nM, respectively). It is also >100-fold selective against ~30 other kinases. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GW843682X, Inhibitor

Full Product Name

GW843682X

Product Gene Name

GW843682X, inhibitor

Product Synonym Names

GW843682

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

477.46

Solubility

DMSO: 33.33mg/mL (69.81mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H18F3N3O4S

SMILES

O=C(C1=C(OCC2=CC=CC=C2C(F)(F)F)C=C(N3C4=CC(OC)=C(OC)C=C4N=C3)S1)N

CAS Number

660868-91-7

Target & IC50

PLK1: ic50 2.2nM
PLK3: ic50 9.1nM
PDGFR1beta: ic50 160nM
VEGFR2: ic50 360nM
Aurora A: ic50 4800nM
CDK2/cyclin A: ic50 7600nM

Product Categories/Family for GW843682X, inhibitor

Cell Cycle/Checkpoint; Angiogenesis; Tyrosine Kinase/Adaptors; Chromatin/Epigenetic

Product References and Citations for GW843682X, inhibitor

Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31.
Lansing TJ, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther. 2007 Feb;6(2):450-9. Epub 2007 Jan 31.
Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591(1-3):102-5.
Didier C, et al. Evaluation of Polo-like Kinase 1 inhibition on the G2/M checkpoint in Acute Myelocytic Leukaemia. Eur J Pharmacol. 2008 Sep 4;591(1-3):102-5.
Ikezoe T, et al. A novel treatment,strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23(9):1564-76.
Ikezoe T, et al. A novel treatment,strategy targeting polo-like kinase 1 in hematological malignancies. Leukemia. 2009 Sep;23(9):1564-76.

Other Notes

Small volumes of GW843682X, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GW843682X purchase

MBS5754942 is an inhibitor targeting GW843682X.