HC-070 Inhibitor

Name: HC-070 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754950
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754950

HC-070 is a TRPC4/TRPC5 antagonist (IC50s: 9.3nM and 46nM for hTRPC5 and hTRPC4 in cells). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HC-070, Inhibitor

Full Product Name

HC-070

Product Gene Name

HC-070, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

475.32

Solubility

DMSO: 62.5mg/mL (131.49mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H20Cl2N4O4

SMILES

O=C(N1CCCO)N(C)C2=C(N(CC3=CC=C(Cl)C=C3)C(OC4=CC=CC(Cl)=C4)=N2)C1=O

CAS Number

1628291-95-1

Target & IC50

hTRPC5, cell assay: ic50 9.3nM
hTRPC4, cell assay: ic50 46nM

In Vitro

HC-070 (1mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. HC-070 (1mg/kg, p.o.) affects mice with increased evoked anxiety (CCK-4) but shows no effects in the absence of CCK-4. HC-070 (0.3, 1 or 3mg/kg, p.o.) reduces anxiety in a standard EPM (more light/high anxiety). HC-070 (0.3, 1, 3, 10mg/kg, p.o.) also reduces the time of immobility in a tail suspension test but does not impact locomotor activity in mice. HC-070 (1, 3, 10mg/kg, p.o.) causes a reduction in marble-burying behavior [1].

Product References and Citations for HC-070, inhibitor

Just S, et al. treatment,with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225.
Just S, et al. treatment,with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225.

Other Notes

Small volumes of HC-070, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HC-070 purchase

MBS5754950 is an inhibitor targeting HC-070.

Additional Details

NCBI/Uniprot data below describe general gene information for HC-070. It may not necessarily be applicable to this product.

Protein Family

Putative uncharacterized protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.