Hesperin Inhibitor

Name: Hesperin Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754954
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754954

Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi). It has been shown to be an activator of Nrf2. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Hesperin, Inhibitor

Full Product Name

Hesperin

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

205.34

Solubility

DMSO: 50mg/mL (243.50mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C8H15NOS2

SMILES

O=S(CCCCCCN=C=S)C

CAS Number

4430-35-7

Target & IC50

Nrf2

In Vitro

Wild-type and Nrf2-null mice are fed the following diets for 12 weeks : 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin to determine whether Hesperin ameliorates hepatic steatosis and iron accumulation. Hesperin activates Nrf2 and causes phase II enzyme genes but this induction is absent in Nrf2-null mice, showing that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. The HFD enhanced hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but does not reduce these triglycerides in Nrf2-null mice[1].

Product Categories/Family for Hesperin, inhibitor

Immunology/Inflammation; Nrf2

Product References and Citations for Hesperin, inhibitor

Tanaka Y, et al. 6-Methylsulfinylhexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1153-1156.
Tanaka Y, et al. 6-Methylsulfinylhexyl isothiocyanate prevents high-fat diet-induced fatty liver but fails to attenuate hepatic iron accumulation in mice. Clin Exp Pharmacol Physiol. 2016 Nov;43(11):1153-1156.
Okamoto T, et al. 6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion. J Nat Med. 2014 Jan;68(1):144-53.
Okamoto T, et al. 6-Methylsulfinylhexyl isothiocyanate modulates endothelial cell function and suppresses leukocyte adhesion. J Nat Med. 2014 Jan;68(1):144-53.

Other Notes

Small volumes of Hesperin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hesperin purchase

MBS5754954 is an inhibitor targeting Hesperin.