• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

HI-TOPK-032 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754958

MBS5754958 is an inhibitor targeting HI-TOPK-032. HI-TOPK-032 is an effective and specific inhibitor of TOPK. More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HI-TOPK-032, Inhibitor
Full Product Name
HI-TOPK-032
Product Gene Name
HI-TOPK-032, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
369.4
Solubility
DMSO: 7.5mg/mL (20.30mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H11N5OS
SMILES
O=C(C1=CC=CS1)NC2=CC3=C(C#N)C4=NC5=CC=CC=C5N=C4N3C=C2
CAS Number
487020-03-1
Target & IC50
Others
In Vitro
HI-TOPK-032 (1 or 10mg/kg; mice) treatment, obviously inhibits HCT-116 tumor growth by more than 60% relative to the vehicle-treated group. Mice are well tolerated with HI-TOPK-032 treatment, The expression of p53 is strongly caused, and phosphorylation of ERK and RSK, a direct downstream protein of ERK. Which is markedly inhibited in the HI-TOPK-032-treated group[1].

Structure of HI-TOPK-032, inhibitor

HI-TOPK-032 Inhibitor – Cat# MBS5754958

Product References and Citations for HI-TOPK-032, inhibitor

Kim DJ, et al. Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 2012 Jun 15;72(12):3060-8.
Kim DJ, et al. Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 2012 Jun 15;72(12):3060-8.

Other Notes

Small volumes of HI-TOPK-032, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000