HIF-2alpha-IN-1 Inhibitor

HIF-2alpha-IN-1 is an inhibitor of HIF-2alpha. In HIF-2alpha scintillation proximity assay, It also has an IC50 of less than 500nM.

Bruick Richard Keith, et al. HIF-2alpha inhibitors for treating iron overload disorders. From PCT Int. Appl. (2016), WO 2016057242 A1 20160414.
Bruick Richard Keith, et al. HIF-2alpha inhibitors for treating iron overload disorders. From PCT Int. Appl. (2016), WO 2016057242 A1 20160414.
Dixon Darryl David, et al. Preparation of cyclic sulfone and sulfoximine analogs as HIF-2alpha inhibitors. From PCT Int. Appl. (2015), WO 2015095048 A1 20150625.
Dixon Darryl David, et al. Preparation of cyclic sulfone and sulfoximine analogs as HIF-2alpha inhibitors. From PCT Int. Appl. (2015), WO 2015095048 A1 20150625.

Small volumes of HIF-2alpha-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5754959 is an inhibitor targeting HIF-2alpha-IN-1.