HOKU-81 Inhibitor

Name: HOKU-81 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754968
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754968

MBS5754968 is an inhibitor targeting HOKU-81. HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

HOKU-81, Inhibitor

Full Product Name

HOKU-81

Product Gene Name

HOKU-81, inhibitor

Product Synonym Names

4-Hydroxytulobuterol

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

243.73

Solubility

DMSO: 50mg/mL (205.15mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C12H18ClNO2

SMILES

ClC1=C(C(O)CNC(C)(C)C)C=CC(O)=C1

CAS Number

58020-43-2

Target & IC50

Others

In Vitro

HOKU-81 was approximately 8 times more potent than tulobuterol, approximately twice as potent as salbutamol, and approximately as potent as isoprenaline in relaxing effect on the isolated tracheal smooth muscle preparation of guinea pigs. HOKU-81 appears to be a potent and selective beta 2-stimulant with a slight inotropic action. Adrenergic Receptor Effects of HOKU-81 on isolated trachea and atria of guinea pigs were compared with those of various bronchodilators. This effect of HOKU-81 seems to be due to direct action on the adrenergic beta-receptor.

Product References and Citations for HOKU-81, inhibitor

Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8.
Kubo S, Matsubara I, Yamazaki M et al. Pharmacological studies of 1-(2-chloro-4-hydroxyphenyl)-2-t-butylaminoethanol (HOKU-81), a new bronchodilator. 1st Communication: Bronchodilator and cardiovascular actions. Arzneimittelforschung. 1980;30(8):1272-8.
Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24.
Gomi Y, Shirahase H, Funato H. Effects of 1-(2-chloro-4-hydroxyphenyl)-t-butylaminoethanol (HOKU-81), a new bronchodilator, on isolated trachea and atria of guinea pig. Jpn J Pharmacol. 1979 Aug;29(4):515-24.

Other Notes

Small volumes of HOKU-81, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

HOKU-81 Inhibitor

Product Overview

Structure of HOKU-81, inhibitor

Related Product Information for HOKU-81, inhibitor

Product References and Citations for HOKU-81, inhibitor

Other Notes