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HQL-79 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754971

HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 uM and IC50: 6uM). It also shows no obvious effect on COX-1, COX-2, m-PGES,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HQL-79, Inhibitor
Full Product Name
HQL-79
Product Gene Name
HQL-79, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
377.48
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C22H27N5O
SMILES
N1(CCCC2=NN=NN2)CCC(OC(C3=CC=CC=C3)C4=CC=CC=C4)CC1
CAS Number
162641-16-9
Target & IC50
H-PGDS: ic50 0.8uM (kd)
In Vitro
HQL-79 is a competitive inhibitor against substrate PGH2. HQL-79 is also a non-competitive one against GSH[1].

Product References and Citations for HQL-79, inhibitor

Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.
Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

Other Notes

Small volumes of HQL-79, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HQL-79 purchase

MBS5754971 is an inhibitor targeting HQL-79.
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