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IDH889 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754980

IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02uM, 0.072uM, and 1.38 uM for IDH1R132H, IDH1R132C, and IDH1wt). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IDH889, Inhibitor
Full Product Name
IDH889
Product Gene Name
IDH889, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
436.48
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C23H25FN6O2
SMILES
O=C1OC[C@H](C(C)C)N1C2=NC(N[C@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2
CAS Number
1429179-07-6
Target & IC50
IDH1R132H: ic50 0.02uM
IDH1R132C: ic50 0.072uM
IDH1wt: ic50 1.38uM

Structure of IDH889, inhibitor

IDH889 Inhibitor – Cat# MBS5754980

Product References and Citations for IDH889, inhibitor

Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDHACS Med Chem Lett. 2016 Dec 16;8(2):151-156.
Levell JR, et al. Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1. ACS Med Chem Lett. 2016 Dec 16;8(2):151-156.

Other Notes

Small volumes of IDH889, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IDH889 purchase

MBS5754980 is an inhibitor targeting IDH889.
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