IK1PA-6 Inhibitor – IK1 Pa-6

Name: IK1PA-6 Inhibitor; IK1 Pa-6; MyBioSource
Brand: MyBioSource
SKU: MBS5754982
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754982

IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15nM for human and mouse KIR2.x currents). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IK1 PA-6 (IK1PA-6), Inhibitor

Full Product Name

IK1 inhibitor PA-6

Product Gene Name

IK1PA-6, inhibitor

Product Synonym Names

PA-6

Form/Format

Solid. Powder

Purity/Purification

98.77%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

492.62

Solubility

DMSO: 120mg/ml (243.59mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C31H32N4O2

SMILES

N=C(NC1=CC=C(OCCCCCOC2=CC=C(NC(=N)C3=CC=CC=C3)C=C2)C=C1)C1=CC=CC=C1

CAS Number

500715-03-7

Target & IC50

KIR2.x currents: ic50 12-15nM

Product Categories/Family for IK1PA-6, inhibitor

Membrane transporter/Ion channel; Potassium Channel

Product References and Citations for IK1PA-6, inhibitor

Takanari H, et al. Efficient and specific cardiac IK1inhibition by a new pentamidine analogue. Cardiovasc Res. 2013 Jul 1;99(1):203-14.
Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590.
Ji Y, et al. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 Aug;174(15):2576-2590.
Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44.
Ji Y, et al. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression. J Biomed Sci. 2017 Jul 15;24(1):44.

Other Notes

Small volumes of IK1PA-6, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IK1PA-6 purchase

MBS5754982 is an inhibitor targeting IK1PA-6. Also known as IK1 inhibitor PA-6.