GSK319347A Inhibitor

Name: GSK319347A Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754984
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754984

GSK319347A is a TBK1 and IKKepsilon dual inhibitor (IC50s: 93nM and 469nM, respectively). GSK319347A inhibits IKK2 (IC50: 790nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSK319347A, Inhibitor

Full Product Name

GSK319347A

Product Gene Name

GSK319347A, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

469.53

Solubility

DMSO: 45mg/mL (95.84mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H19N3O5S2

SMILES

COC1=CC2=C(C=C1OC)N(C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)C=N2

CAS Number

862812-98-4

Target & IC50

TBK1: ic50 93nM
IKK-epsilon: ic50 469nM
IKK2: ic50 790nM

Product Categories/Family for GSK319347A, inhibitor

NF-kappab; IkappaB/IKK

Product References and Citations for GSK319347A, inhibitor

Johannes JW, et al. Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-epsilon kinases. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1138-43.
Johannes JW, et al. Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-epsilon kinases. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1138-43.
Xie HZ, et al. Pharmacophore modeling and hybrid virtual screening for the discovery of novel IkappaB kinase 2 (IKK2) inhibitors. J Biomol Struct Dyn. 2011 Aug;29(1):165-79.
Xie HZ, et al. Pharmacophore modeling and hybrid virtual screening for the discovery of novel IkappaB kinase 2 (IKK2) inhibitors. J Biomol Struct Dyn. 2011 Aug;29(1):165-79.

Other Notes

Small volumes of GSK319347A, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GSK319347A purchase

MBS5754984 is an inhibitor targeting GSK319347A.