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IMD-0560 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754989

MBS5754989 is an inhibitor targeting IMD-0560. IMD-0560 is a novel inhibitor of IkappaB kinase beta. More details

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Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IMD-0560, Inhibitor
Full Product Name
IMD-0560
Product Gene Name
IMD-0560, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
428.12
Solubility
Ethanol: 50mg/mL (116.79mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C15H8BrF6NO2
SMILES
O=C(C1=C(C=CC(Br)=C1)O)NC2=C(C=CC(C(F)(F)F)=C2)C(F)(F)F
CAS Number
439144-66-8
Target & IC50
IKKbeta
In Vitro
Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5mg/kg IMD-0560. The inhibitory effect of each treatment,on zygoma destruction is similar, although the tumor size in the 5mg/kg IMD-0560-treated group is smaller than that of the 3mg/kg IMD-0560-treated group[1].

Product Categories/Family for IMD-0560, inhibitor

NF-kappab; IkappaB/IKK

Structure of IMD-0560, inhibitor

IMD-0560 Inhibitor – Cat# MBS5754989

Product References and Citations for IMD-0560, inhibitor

Tada Y, et al. The novel IkappaB kinase beta inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.
Tada Y, et al. The novel IkappaB kinase beta inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30.

Other Notes

Small volumes of IMD-0560, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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