Imrecoxib Inhibitor

Name: Imrecoxib Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5754992
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754992

Imrecoxib is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18nM). It also inhibits COX1- activity (IC50: 115nM). Imrecoxib has an anti-inflammatory effect. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Imrecoxib, Inhibitor

Full Product Name

Imrecoxib

Product Synonym Names

BAP-909

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

369.48

Solubility

DMSO: 100mg/mL (270.65mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C21H23NO3S

SMILES

O=C1N(CCC)CC(C2=CC=C(S(=O)(C)=O)C=C2)=C1C3=CC=C(C)C=C3

CAS Number

395683-14-4

Target & IC50

Human COX-1: ic50 115nM
Human COX-2: ic50 18nM

In Vitro

Imrecoxib (gastrointestinal administration; 5-20mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling. It also inhibits heat-inactivated BCG induced-inflammtory polyarthritis. Imrecoxib (gastrointestinal administration; 5-20mg/kg; 1 hour before carrageenan injection) suppresses carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours[1].

Product Categories/Family for Imrecoxib, inhibitor

Immunology/Inflammation; COX; Neuroscience

Product References and Citations for Imrecoxib, inhibitor

Chen XH, et al. Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect. Acta Pharmacol Sin. 2004 Jul;25(7):927-31.
Chen XH, et al. Imrecoxib: a novel and selective cyclooxygenase 2 inhibitor with anti-inflammatory effect. Acta Pharmacol Sin. 2004 Jul;25(7):927-31.

Other Notes

Small volumes of Imrecoxib, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Imrecoxib purchase

MBS5754992 is an inhibitor targeting Imrecoxib.