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Indotecan Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5754998

Indotecan is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560nM for P388, HCT116, MCF-7 cell lines, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Indotecan, Inhibitor
Full Product Name
Indotecan
Product Synonym Names
LMP-400; NSC-724998
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
478.49
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C26H26N2O7
SMILES
O=C1C2=CC(OC)=C(OC)C=C2C3=C(C(C=C(OCO4)C4=C5)=C5C3=O)N1CCCN6CCOCC6
CAS Number
915303-09-2
Target & IC50
P388: ic50 300nM
HCT116: ic50 1200nM
MCF-7 cell lines: ic50 560nM

Structure of Indotecan, inhibitor

Indotecan Inhibitor – Cat# MBS5754998

Product References and Citations for Indotecan, inhibitor

Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.
Seol Y, et al. Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors. Mol Cancer Ther. 2015 Nov;14(11):2552-9.

Other Notes

Small volumes of Indotecan, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Indotecan purchase

MBS5754998 is an inhibitor targeting Indotecan.
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