IRL2500 Inhibitor – IRL 2500

Name: IRL2500 Inhibitor; IRL 2500; MyBioSource
Brand: MyBioSource
SKU: MBS5755006
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755006

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. IRL 2500 displays (IC50:1.3 and 94nM for ETB and ETA receptors, respectively). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IRL 2500 (IRL2500), Inhibitor

Full Product Name

IRL 2500

Product Gene Name

IRL2500, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

573.68

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C36H35N3O4

SMILES

O=C(O)[C@H](CC1=CNC2=CC=CC=C12)NC([C@@H](CC3=CC=C(C4=CC=CC=C4)C=C3)N(C(C5=CC(C)=CC(C)=C5)=O)C)=O

CAS Number

169545-27-1

Target & IC50

ETB: ic50 1.3nM
ETA: ic50 94nM

Product References and Citations for IRL2500, inhibitor

Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
Webb RL, et al. Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S389-92.
Webb RL, et al. Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S389-92.

Other Notes

Small volumes of IRL2500, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRL2500 purchase

MBS5755006 is an inhibitor targeting IRL2500. Also known as IRL 2500.

IRL2500 Inhibitor – IRL 2500

Product Overview

Structure of IRL2500, inhibitor

Related Product Information for IRL2500, inhibitor

Product References and Citations for IRL2500, inhibitor

Other Notes

Searchable Terms for IRL2500 purchase