IU1-47 Inhibitor

Name: IU1-47 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755012
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755012

IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6uM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IU1-47, Inhibitor

Full Product Name

IU1-47

Product Gene Name

IU1-47, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

330.85

Solubility

DMSO: 16.67mg/mL (50.39mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H23ClN2O

SMILES

CC1=CC(C(CN2CCCCC2)=O)=C(N1C3=CC=C(C=C3)Cl)C

CAS Number

670270-31-2

Target & IC50

USP14: ic50 0.6uM
IsoT/USP5: ic50 20uM

Product Categories/Family for IU1-47, inhibitor

Ubiquitination; DUB

Product References and Citations for IU1-47, inhibitor

Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225.
Boselli M, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

Other Notes

Small volumes of IU1-47, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IU1-47 purchase

MBS5755012 is an inhibitor targeting IU1-47.