JAK3-IN-1 Inhibitor

Name: JAK3-IN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755014
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755014

JAK3-IN-1 is a selective and orally active JAK3 inhibitor (IC50: 4.8nM). JAK3-IN-1 displays over 180-fold more selective for JAK3 than JAK1 (IC50: 896nM) and JAK2 (IC50: 1050nM). More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JAK3-IN-1, Inhibitor

Full Product Name

JAK3-IN-1

Product Gene Name

JAK3-IN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

508.02

Solubility

DMSO: 47mg/mL (92.52mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C26H30ClN7O2

SMILES

O=C(C=C)NC1=CC(CNC2=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=CC=C1

CAS Number

1805787-93-2

Target & IC50

JAK3: ic50 4.8nM
JAK1: ic50 896nM
JAK2: ic50 1050nM
TTK: ic50 49nM
BTK: ic50 794nM
ITK: ic50 1070nM

In Vitro

The numbers of B or T lymphocytes in the tumor-bearing lungs and spleens of treated mice is not affected, after oral administration with JAK3-IN-1(Compound 9) (75mpk, QD) for 8 days, however, the number of NK cells is reduced. JAK3-IN-1 displays reasonable pharmacokinetic properties, with moderate T1/2 of 1.4 h, area under the curve (AUC) value of 795 ng*hr/mL following a 10mg/Kg oral dose and good oral bioavailability of 66% [1].

Product Categories/Family for JAK3-IN-1, inhibitor

Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Tyrosine Kinase/Adaptors; Stem Cells

Product References and Citations for JAK3-IN-1, inhibitor

Tan L, et al. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-6606.
Tan L, et al. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-6606.

Other Notes

Small volumes of JAK3-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAK3-IN-1 purchase

MBS5755014 is an inhibitor targeting JAK3-IN-1.