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Jarin-1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755015

Jarin-1 is a jasmonic acid-amido synthetase (JAR1) inhibitor (IC50: 3.8 uM). Jarin-1 specific suppresses bioactive JA biosynthesis in Arabidopsis and other plants. More details

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Product Documentation
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Jarin-1, Inhibitor
Full Product Name
Jarin-1
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
471.55
Solubility
<1mg/ml refers to the product slightly soluble or insoluble
Formula
C28H29N3O4
SMILES
O=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC(C3=O)=CC=C4N3C[C@]5([H])CN(C(CCOC)=O)C[C@@]4([H])C5
CAS Number
1212704-51-2
Target & IC50
Jasmonic acid-amido synthetase (JAR1)
In Vitro
MeJA + Jarin-1 treatment, caused an upregulation of FaANR and associated transcription factors such as FabHLH33 and FaMYB9/11 along with FaJMT and FaJAR1.2. JA-responsive elements in the promoter regions of FaMYB1/9/10/11 genes are found. The proanthocyanidin (PA) content was higher in Jarin-1- and MeJA + Jarin-1-treated than in MeJA-treated fruits. PA biosynthesis-related genes can be upregulated by the application of Jarin-1 to MeJA-treated fruit, thus increasing PA accumulation in strawberry. A higher redness of strawberry fruit skin and anthocyanin content in MeJA-treated fruits with respect to Jarin-1-treated ones concomitant with an upregulation of FaANS and FaUFGT genes is found[1].

Structure of Jarin-1, inhibitor

Jarin-1 Inhibitor – Cat# MBS5755015

Product References and Citations for Jarin-1, inhibitor

Delgado LD, et al. Application of a JA-Ile Biosynthesis Inhibitor to Methyl Jasmonate-Treated Strawberry Fruit Induces Upregulation of Specific MBW Complex-Related Genes and Accumulation of Proanthocyanidins. Molecules. 2018 Jun 13;23(6). pii: E1433.
Delgado LD, et al. Application of a JA-Ile Biosynthesis Inhibitor to Methyl Jasmonate-Treated Strawberry Fruit Induces Upregulation of Specific MBW Complex-Related Genes and Accumulation of Proanthocyanidins. Molecules. 2018 Jun 13;23(6). pii: E1433.
Meesters C, et al. A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. Nat Chem Biol. 2014 Oct;10(10):830-6.
Meesters C, et al. A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. Nat Chem Biol. 2014 Oct;10(10):830-6.

Other Notes

Small volumes of Jarin-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Jarin-1 purchase

MBS5755015 is an inhibitor targeting Jarin-1.
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