JH-RE-06 Inhibitor

Name: JH-RE-06 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755018
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755018

JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLzeta. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 uM; Kd=0.42uM), which targets REV1 that interacts with the REV7 subunit of POLzeta.… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JH-RE-06, Inhibitor

Full Product Name

JH-RE-06

Product Gene Name

JH-RE-06, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

468.72

Solubility

DMSO: 5mg/mL (10.67mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H16Cl3N3O4

SMILES

O=C1C(C(CC(C)C)=O)=C(NC2=CC=C(Cl)C=C2Cl)NC3=C1C([N+]([O-])=O)=CC=C3Cl

CAS Number

1361227-90-8

Target & IC50

REV1-REV7: ic50

In Vitro

In mice, co-administration of JH-RE-06 with cisplatin inhibits the growth of xenograft human melanomas. JH-RE-06 suppresses mutagenic TLS and increases cisplatin-induced toxicity in cultured human and mouse cell lines [1].

Product Categories/Family for JH-RE-06, inhibitor

DNA Damage/DNA Repair; DNA/RNA Synthesis

Product References and Citations for JH-RE-06, inhibitor

Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019 Jun 27;178(1):152-159.e11.
Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019 Jun 27;178(1):152-159.e11.
REV1-POLÏ‚ Inhibition Enhances Cisplatin-Induced Cytotoxicity. Cancer Discov. 2019 Aug;9(8):OF17.
REV1-POLÏ‚ Inhibition Enhances Cisplatin-Induced Cytotoxicity. Cancer Discov. 2019 Aug;9(8):OF17.

Other Notes

Small volumes of JH-RE-06, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JH-RE-06 purchase

MBS5755018 is an inhibitor targeting JH-RE-06.