JNJ-46281222 Inhibitor

Name: JNJ-46281222 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755025
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755025

JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7nM) and a high modulatory potency (pEC50 = 7.71). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

JNJ-46281222, Inhibitor

Full Product Name

JNJ-46281222

Product Gene Name

JNJ-46281222, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

414.47

Solubility

DMSO: 62.5mg/mL (150.79mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C23H25F3N4

SMILES

FC(C1=C(CN2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F

CAS Number

1254980-38-5

Target & IC50

mGluR2: ic50 1.7nM (kd)

Product Categories/Family for JNJ-46281222, inhibitor

Neuroscience; GluR

Product References and Citations for JNJ-46281222, inhibitor

Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222. Br J Pharmacol. 2016 Feb;173(3):588-600.
Doornbos ML,et al. Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222. Br J Pharmacol. 2016 Feb;173(3):588-600.

Other Notes

Small volumes of JNJ-46281222, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JNJ-46281222 purchase

MBS5755025 is an inhibitor targeting JNJ-46281222.