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JNJ-46778212 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755026

MBS5755026 is an inhibitor targeting JNJ-46778212. JNJ-46778212 is an effective mGlu5 allosteric modulator (EC50: 260nM). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JNJ-46778212, Inhibitor
Full Product Name
JNJ-46778212
Product Gene Name
JNJ-46778212, inhibitor
Product Synonym Names
VU 0409551
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
352.36
Solubility
DMSO: 125mg/mL (354.75mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H17FN2O3
SMILES
O=C(N1CCC2=C(OC(COC3=CC=CC=C3)=N2)C1)C4=CC=C(F)C=C4
CAS Number
1363281-27-9
Target & IC50
mGlu5: ic50 260nM (EC50)

Product Categories/Family for JNJ-46778212, inhibitor

Neuroscience; GluR

Structure of JNJ-46778212, inhibitor

JNJ-46778212 Inhibitor – Cat# MBS5755026

Product References and Citations for JNJ-46778212, inhibitor

Conde-Ceide S, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20.
Conde-Ceide S, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20.

Other Notes

Small volumes of JNJ-46778212, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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