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JNJ-678 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755027

JNJ-678 is a novel inhibitor of the fusion protein. JNJ-678 shows the potential for respiratory syncytial virus (RSV) treatment. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JNJ-678, Inhibitor
Full Product Name
JNJ-678
Product Gene Name
JNJ-678, inhibitor
Product Synonym Names
JNJ-53718678
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
500.92
Solubility
DMSO: 65mg/mL (129.76mM) Need ultrasonic
H2O: <0.1mg/mL (insoluble)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C21H20ClF3N4O3S
SMILES
O=C(N1CC(F)(F)F)N(CC(N2CCCS(=O)(C)=O)=CC3=C2C=CC(Cl)=C3)C4=C1C=CN=C4
CAS Number
1383450-81-4
Target & IC50
Fusion protein
In Vitro
JNJ-678 efficiently suppresses established acute lower respiratory tract infection in the animals after oral treatment of neonatal lambs with JNJ-678, or with an equally active close analog, even when treatment,is delayed until external signs of respiratory syncytial virus illness have become visible[1].

Structure of JNJ-678, inhibitor

JNJ-678 Inhibitor – Cat# MBS5755027

Product References and Citations for JNJ-678, inhibitor

Roymans D, et al. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun. 2017 Aug 1;8(1):167.
Roymans D, et al. Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor. Nat Commun. 2017 Aug 1;8(1):167.

Other Notes

Small volumes of JNJ-678, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JNJ-678 purchase

MBS5755027 is an inhibitor targeting JNJ-678.
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