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JTE-013 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755033

JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17nM and 22nM, respectively). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
JTE-013, Inhibitor
Full Product Name
JTE-013
Product Gene Name
JTE-013, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
408.29
Solubility
DMSO: 100mg/mL (244.92mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H19Cl2N7O
SMILES
CC(C1=C2C(N(C)N=C2C)=NC(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)=C1)C
CAS Number
383150-41-2
Target & IC50
S1P2 for human: ic50 17nM
S1P2 for rat: ic50 22nM
In Vitro
JTE-013 (gavage; 30mg/kg daily for 14 consecutive days) decreases tumor size and tumor weight[1].

Structure of JTE-013, inhibitor

JTE-013 Inhibitor – Cat# MBS5755033

Product References and Citations for JTE-013, inhibitor

Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.
Li MH, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. 2015 Sep;354(3):261-8.

Other Notes

Small volumes of JTE-013, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JTE-013 purchase

MBS5755033 is an inhibitor targeting JTE-013.
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