L-371,257 Inhibitor

Name: L-371,257 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755058
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755058

L-371,257 is a non-blood-brain barrier penetrant and competitive antagonist of oxytocin receptor (pA2=8.4). It also has high affinity at both the oxytocin receptor (Ki=19nM) and the vasopressin V1a receptor (Ki=3.7nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

L-371,257, Inhibitor

Full Product Name

L-371,257

Product Gene Name

L-371,257, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

507.58

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C28H33N3O6

SMILES

O=C(OC1)N(C2CCN(C(C3=C(OC)C=C(OC4CCN(C(C)=O)CC4)C=C3)=O)CC2)C5=C1C=CC=C5

CAS Number

162042-44-6

Target & IC50

oxytocin receptor: ic50 19nM (ki)
vasopressin V1a receptor: ic50 3.7nM (ki)

Product Categories/Family for L-371,257, inhibitor

Endocrinology/Hormones; GPCR/G Protein

Product References and Citations for L-371,257, inhibitor

Williams PD, et al. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem. 1995 Nov 10;38(23):4634-6.
Williams PD, et al. 1-(1-[4-[(N-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]piperidin-4- yl)-4H-3,1-benzoxazin-2(1H)-one (L-371,257): a new, orally bioavailable, non-peptide oxytocin antagonist. J Med Chem. 1995 Nov 10;38(23):4634-6.
Tunstall BJ, et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol. 2019 Apr 16;17(4):e2006421.
Tunstall BJ, et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. PLoS Biol. 2019 Apr 16;17(4):e2006421.

Other Notes

Small volumes of L-371,257, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L-371,257 purchase

MBS5755058 is an inhibitor targeting L-371,257.