L-690330 Inhibitor

L-690330 is a competitive inositol monophosphatase inhibitor (Kis: 0.27 and 0.19 uM for recombinant human and bovine IMPase, 0.30 and 0.42uM for human and bovine frontal cortex IMPase). L-690330 shows 10-fold more sensitive than a mouse and rat IMPase.

Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8.
Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8.
Cardenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83.
Cardenas C, et al. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Cell. 2010 Jul 23;142(2):270-83.
Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8.
Shtein L, et al. The inositol monophosphatase inhibitor L-690,330 affects pilocarpine-behavior and the forced swim test.Psychopharmacology (Berl). 2013 Jun;227(3):503-8.

Small volumes of L-690330, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5755059 is an inhibitor targeting L-690330.