Laninamivir Inhibitor

Name: Laninamivir Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755070
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755070

Laninamivir is an effective inhibitor of influenza neuraminidase (NA) (IC50s: 0.90nM, 1.83nM, and 3.12nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Laninamivir, Inhibitor

Full Product Name

Laninamivir

Product Synonym Names

R 125489

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

346.34

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C13H22N4O7

SMILES

[H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](OC)[C@H](O)CO

CAS Number

203120-17-6

Target & IC50

N5: ic50 0.90nM
p09N1: ic50 1.83nM
p57N2: ic50 3.12nM

In Vitro

Laninamivir is effective against p57N2, p09N1, and N5 with a similar binding mode to Zanamivir. Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution [1].

Product Categories/Family for Laninamivir, inhibitor

Anti-infection; Microbiology&virology

Product References and Citations for Laninamivir, inhibitor

Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.
Vavricka CJ, et al. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.

Other Notes

Small volumes of Laninamivir, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Laninamivir purchase

MBS5755070 is an inhibitor targeting Laninamivir.