LLY-283 Inhibitor

Name: LLY-283 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755108
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755108

LLY-283 is an effective and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) (IC50: 22nM and a Kd: 6nM for PRMT5:MEP50 complex). It also shows antitumor activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LLY-283, Inhibitor

Full Product Name

LLY-283

Product Gene Name

LLY-283, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

342.35

Solubility

DMSO: 250mg/mL (730.25mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C17H18N4O4

SMILES

O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC=CC=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3

CAS Number

2040291-27-6

Target & IC50

PRMT5, MEP50: ic50 6nM (ki)

In Vitro

After treatment, for 28 days, LLY-283 (20mg/kg; p.o., QD (once a day)) induces a significant inhibition on tumor growth in mice bearing A375 cells.

Product Categories/Family for LLY-283, inhibitor

Chromatin/Epigenetic

Product References and Citations for LLY-283, inhibitor

Zahid Q. Bonday, et al. LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med. Chem. Lett., 2018, 9 (7), pp 612-617.

Other Notes

Small volumes of LLY-283, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LLY-283 purchase

MBS5755108 is an inhibitor targeting LLY-283.