LX-1031 Inhibitor

Name: LX-1031 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755127
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755127

LX-1031 is an effective and orally available inhibitor of tryptophan 5-hydroxylase (TPH). It also decreases serotonin (5-HT) synthesis peripherally. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LX-1031, Inhibitor

Full Product Name

LX-1031

Product Gene Name

LX-1031, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

538.52

Solubility

DMSO: 34mg/mL (63.14mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H25F3N4O4

SMILES

NC1=NC(C2=CC=C(C=C2)C[C@@H](C(O)=O)N)=CC(O[C@H](C3=CC=C(C4=CC(OC)=CC=C4)C=C3)C(F)(F)F)=N1

CAS Number

945976-76-1

Target & IC50

Others

In Vitro

The effects of LX-1031, 100mg/kg daily, on 5-HT levels in jejunal mucosa are reversible within 2 days of discontinuation in mice[1]. LX-1031 dose-dependently decreases expression of 5-HT in the duodenum, jejunum, and ileum, but has no effect on brain 5-HT levels in preclinical assay[2]. LX-1031 (p.o.; in mice), the average 5-HT reductions in the jejunum relative to control are appr 33, 51, and 66% with the 15, 45 and 135mg/kg/day doses respectively.

Product Categories/Family for LX-1031, inhibitor

GPCR/G Protein; LPA Receptor; Others

Product References and Citations for LX-1031, inhibitor

Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.
Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterol Motil. 2011 Mar;23(3):193-200.
Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment,of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8.
Camilleri M. LX-1031, a tryptophan 5-hydroxylase inhibitor that reduces 5-HT levels for the potential treatment,of irritable bowel syndrome. IDrugs. 2010 Dec;13(12):921-8.

Other Notes

Small volumes of LX-1031, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LX-1031 purchase

MBS5755127 is an inhibitor targeting LX-1031.