LY2794193 Inhibitor

Name: LY2794193 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755135
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755135

LY2794193 is a highly effective and selective agonist of the mGlu3 receptor (hmGlu3 Ki=0.927nM,EC50=0.47nM; hmGlu2 Ki=412nM,EC50=47.5nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LY2794193, Inhibitor

Full Product Name

LY2794193

Product Gene Name

LY2794193, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

334.32

Solubility

H2O: 2mg/mL (5.98mM) ultrasonic and adjust pH to 14 with NaOH
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C16H18N2O6

SMILES

O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])[C@@H](NC(C3=CC=CC(OC)=C3)=O)C1)O

CAS Number

2173037-97-1

Target & IC50

mGluR3: ic50 0.927nM (ki)
mGluR2: ic50 412 (ki)

In Vitro

LY2794193 shows inhibition of spontaneous Ca2+ oscillations in cultured rat cortical neurons (EC50: 43.6nM). LY2794193 shows a biphasic inhibition of spontaneous Ca2+ transients (high-affinity EC50=0.44nM; 48% of the total agonist response; low-affinity EC50=43.6nM; 52% of the total agonist response), in the rat cortical neuron Ca2+ oscillation assay, with combined maximal agonist efficacy (Emax) of 66%.

Product Categories/Family for LY2794193, inhibitor

GPCR/G Protein; SGLT; Neuroscience

Product References and Citations for LY2794193, inhibitor

Monn JA, et al. Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3 Receptor Agonist. J Med Chem. 2018 Mar 22;61(6):2303-2328.

Other Notes

Small volumes of LY2794193, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY2794193 purchase

MBS5755135 is an inhibitor targeting LY2794193.