LY2812223 Inhibitor

Name: LY2812223 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755137
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755137

LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144nM and 156nM, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LY2812223, Inhibitor

Full Product Name

LY2812223

Product Gene Name

LY2812223, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

284.29

Solubility

H2O: 50mg/mL (175.88mM) Need ultrasonic
DMSO: 28.75mg/mL (101.13mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C10H12N4O4S

SMILES

[H][C@]1(C(O)=O)[C@]([C@]1([H])[C@](N)(C(O)=O)C2)([H])[C@@H]2SC3=NN=CN3

CAS Number

1311385-20-2

Target & IC50

mGluR2: ic50 144nM (ki)
mGluR3: ic50 156nM (ki)

Product Categories/Family for LY2812223, inhibitor

Cell Cycle/Checkpoint; LIM Kinase; Neuroscience

Product References and Citations for LY2812223, inhibitor

Monn JA, et al. Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. J Med Chem. 2015 Sep 24;58(18):7526-48.

Other Notes

Small volumes of LY2812223, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY2812223 purchase

MBS5755137 is an inhibitor targeting LY2812223.