LY2922470 Inhibitor

Name: LY2922470 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755138
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755138

LY2922470 reduces glucose levels along with significant enhancements in insulin and GLP-1, which is the potential for the treatment,of type 2 diabetes mellitus (T2DM). LY2922470 is an effective, selective, and orally available agonist of the G protein-coupled… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LY2922470, Inhibitor

Full Product Name

LY2922470

Product Gene Name

LY2922470, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

475.6

Solubility

DMSO: 125mg/mL (262.83mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C28H29NO4S

SMILES

COC1=C(N(CC2=CC=C(COC3=CC=C([C@@H](C#CC)CC(O)=O)C=C3)S2)CCC4)C4=CC=C1

CAS Number

1423018-12-5

Target & IC50

human GPR40: ic50 7nM (EC50)
mouse GPR40: ic50 1nM (EC50)
rat GPR40: ic50 3nM (EC50)

Product Categories/Family for LY2922470, inhibitor

GPCR/G Protein; PKA; Endocrinology/Hormones

Product References and Citations for LY2922470, inhibitor

Hamdouchi C, et al. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the treatment,of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). J Med Chem. 2016 Dec 22;59(24):10891-10916.

Other Notes

Small volumes of LY2922470, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY2922470 purchase

MBS5755138 is an inhibitor targeting LY2922470.