LY2955303 Inhibitor

Name: LY2955303 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755139
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755139

LY2955303 is an effective and selective retinoic acid receptor gamma (RARgamma) antagonist (Ki: 1.09nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LY2955303, Inhibitor

Full Product Name

LY2955303

Product Gene Name

LY2955303, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

578.74

Solubility

DMSO: 30mg/mL (51.84mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C36H42N4O3

SMILES

CC(C)(C1=CC(C(C)(C)C)=CC(C2=CC(C3=CC=C(C(O)=O)C=C3)=NN2C4=CC=C(C(N5CCN(C)CC5)=O)C=C4)=C1)C

CAS Number

1433497-19-8

Target & IC50

RARgamma: ic50 1.09nM (ki)

In Vitro

LY2955303(p.o.) shows a dose-responsive effect whereby the rat decreases differential weight-bearing (ED50=0.72mg/kg).

Product Categories/Family for LY2955303, inhibitor

Metabolism

Product References and Citations for LY2955303, inhibitor

Hughes NE, et al. Identification of potent and selective retinoic acid receptor gamma (RARgamma) antagonists for the treatment,of osteoarthritis pain using structure based drug design. Bioorg Med Chem Lett. 2016 Jul 15;26(14):3274-3277.

Other Notes

Small volumes of LY2955303, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY2955303 purchase

MBS5755139 is an inhibitor targeting LY2955303.