ML224 Inhibitor

Name: ML224 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755207
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755207

ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ML224, Inhibitor

Full Product Name

ML224

Product Gene Name

ML224, inhibitor

Product Synonym Names

NCGC00242364; ANTAG3

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

525.59

Solubility

DMSO: 100mg/mL (190.26mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C31H31N3O5

SMILES

CC(NC1=CC(C)=C(OCC2=CC(C(N3CC4=CC=CO4)NC5=C(C=CC=C5)C3=O)=CC=C2OC)C(C)=C1)=O

CAS Number

1338824-21-7

Target & IC50

Others

In Vitro

ANTAG3 lowered serum-free T4 by 44% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 75% and 83%, respectively, in mice treated with TRhours. ANTAG3 lowered serum-free T4 by 38% and lowered mRNAs for sodium-iodide cotransporter and thyroperoxidase by 73% and 40%, respectively, in mice given M22 [2].

Product Categories/Family for ML224, inhibitor

Proteases/Proteasome; Cysteine Protease; Others

Product References and Citations for ML224, inhibitor

Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program
Huang W, et al. Identification of Thyroid Stimulating Hormone Receptor Inverse Agonists. Probe Reports from the NIH Molecular Libraries Program
Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.
Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155(1):310-4.

Other Notes

Small volumes of ML224, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ML224 purchase

MBS5755207 is an inhibitor targeting ML224.