MLN-4760 Inhibitor

Name: MLN-4760 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755215
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755215

MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100uM) and bovine carboxypeptidase A (CPDA; IC50, 27 uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MLN-4760, Inhibitor

Full Product Name

MLN-4760

Product Gene Name

MLN-4760, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

428.31

Solubility

DMSO: 199mg/mL (464.62mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H23Cl2N3O4

SMILES

CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O

CAS Number

305335-31-3

Target & IC50

Human ACE2: ic50 0.44nM
Bovine carboxypeptidase A: ic50 27uM

Product Categories/Family for MLN-4760, inhibitor

Endocrinology/Hormones

Product References and Citations for MLN-4760, inhibitor

Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.
Dales NA, et al. Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. J Am Chem Soc. 2002 Oct 9;124(40):11852-3.
Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33.
Joshi S, et al. Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cells. Eur J Pharmacol. 2016 Mar 5;774:25-33.
Bennion DM, et al. Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke. Hypertension. 2015 Jul;66(1):141-8.
Bennion DM, et al. Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke. Hypertension. 2015 Jul;66(1):141-8.

Other Notes

Small volumes of MLN-4760, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLN-4760 purchase

MBS5755215 is an inhibitor targeting MLN-4760.