MLT-748 Inhibitor

Name: MLT-748 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755218
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755218

MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MLT-748, Inhibitor

Full Product Name

MLT-748

Product Gene Name

MLT-748, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

492.32

Solubility

DMSO: 250mg/mL (507.80mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H19Cl2N9O3

SMILES

O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([C@@H](OC)[C@H](OC)C)N4C(N=C3)=CC(Cl)=N4

CAS Number

1832578-30-9

Target & IC50

MALT1: ic50 5nM
MALT1329-728-W580S: ic50 13nM (kd)
MALT1329-728: ic50 42nM (kd)

Product Categories/Family for MLT-748, inhibitor

Immunology/Inflammation

Product References and Citations for MLT-748, inhibitor

Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313.

Other Notes

Small volumes of MLT-748, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLT-748 purchase

MBS5755218 is an inhibitor targeting MLT-748.