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MRS-1191 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755226

MRS-1191 is an effective and selective A3 adenosine receptor antagonist (KB: 92nM, a Ki: 31.4nM for human A3 receptor and an IC50: 120nM for CHO cells). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
MRS-1191, Inhibitor
Full Product Name
MRS-1191
Product Gene Name
MRS-1191, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
477.55
Solubility
DMSO: 250mg/mL (523.51mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C31H27NO4
SMILES
O=C(OCC)C1=C(NC(C2=CC=CC=C2)=C(C1C#CC3=CC=CC=C3)C(OCC4=CC=CC=C4)=O)C
CAS Number
185222-90-6
Target & IC50
human A3 adenosine receptor: ic50 31.4nM (ki)
In Vitro
MRS-1191 is found to be competitive in saturation binding studies using the agonist radioligand [125I]AB-MECA (N6-(4-amino-3-iodobenzyl)adenosine-5'-N-methylbromide) at cloned human brain A3 receptor expressed in HEK-293 cells. The effects of putative A3 adenosine receptor antagonist of MRS-1191 is characterized in receptor binding and functional assays. MRS-1191 with a KB value of 92nM, proves to be highly selective for human A3 receptor vs human A1 receptor-mediated effects on adenylate cyclase.

Structure of MRS-1191, inhibitor

MRS-1191 Inhibitor – Cat# MBS5755226

Product References and Citations for MRS-1191, inhibitor

Jacobson KA, et al. Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology. 1997 Sep;36(9):1157-65.

Other Notes

Small volumes of MRS-1191, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRS-1191 purchase

MBS5755226 is an inhibitor targeting MRS-1191.
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