MS-444 Inhibitor

Name: MS-444 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755231
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755231

MS-444 suppresses the activity of purified smooth muscle myosin light chain kinase (MLCK) (IC50: 10uM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MS-444, Inhibitor

Full Product Name

MS-444

Product Gene Name

MS-444, inhibitor

Product Synonym Names

BE-34776

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

230.22

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C13H10O4

SMILES

O=C(C1=C(C)OC=C1C2)C3=C2C(O)=CC=C3O

CAS Number

150045-18-4

Target & IC50

myosin: ic50 10uM

In Vitro

Mice bearing HCT116 cell xenografts receive IP injections of MS-444 (25mg/kg bw) or vehicle every 48 hours to test the effects of MS-444 on CRC cell growth in vivo. Over the experiment course, mice do not show any adverse effects and maintained similar weights. Anti-tumor effects of MS-444 are observed with an approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 shows a marked 2- to 3-fold reduction in microvessel density (MVD), showing the anti-angiogenic potential of MS-444[2].

Product References and Citations for MS-444, inhibitor

Satoshi Nakanishi. et al. MS-444, a new inhibitor of myosin light chain kinase from
Satoshi Nakanishi. et al. MS-444, a new inhibitor of myosin light chain kinase from
Fernando F. Blanco.et al, Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016 Nov 8; 7(45): 74043-74058.
Fernando F. Blanco.et al, Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016 Nov 8; 7(45): 74043-74058.

Other Notes

Small volumes of MS-444, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MS-444 purchase

MBS5755231 is an inhibitor targeting MS-444.

Additional Details

NCBI/Uniprot data below describe general gene information for MS-444. It may not necessarily be applicable to this product.

Protein Family

Zinc finger protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.