MS417 Inhibitor

Name: MS417 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755233
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755233

MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46nM and Kds of 36.1, 25.4nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 uM. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MS417, Inhibitor

Full Product Name

MS417

Product Gene Name

MS417, inhibitor

Product Synonym Names

GTPL7512

Form/Format

Solid. Powder

Purity/Purification

99.88%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

414.91

Solubility

Ethanol: 50mg/mL (120.51mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H19ClN4O2S

SMILES

COC(=O)C[C@@H]1N=C(C2=C(SC(C)=C2C)N2C(C)=NN=C12)C1=CC=C(Cl)C=C1

CAS Number

916489-36-6

Target & IC50

BRD4-BD1: ic50 30nM
BRD4-BD2: ic50 46nM
CBP BRD: ic50 32.7uM

Product Categories/Family for MS417, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain

Product References and Citations for MS417, inhibitor

Zhang G, et al. Down-regulation of NF-kappaB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51.
Zhang G, et al. Down-regulation of NF-kappaB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem. 2012 Aug 17;287(34):28840-51.
Cheng-Ming, Chiang. Phospho-BRD4: transcription plasticity and drug targeting[J]. Drug Discovery Today Technologies, 2016.
Cheng-Ming, Chiang. Phospho-BRD4: transcription plasticity and drug targeting[J]. Drug Discovery Today Technologies, 2016.

Other Notes

Small volumes of MS417, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MS417 purchase

MBS5755233 is an inhibitor targeting MS417.