MT-802 Inhibitor

Name: MT-802 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755235
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755235

MT-802 is an effective BTK degrader based on PROTAC technology (DC50: 1nM). MT-802 has the potential to treat C481S mutant chronic lymphocytic leukemia (CLL). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MT-802, Inhibitor

Full Product Name

MT-802

Product Gene Name

MT-802, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

787.82

Solubility

DMSO: 100mg/mL (126.93mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C41H41N9O8

SMILES

O=C(NC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)COCCOCCN4CCC(N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C(N)N=CN=C85)CC4

CAS Number

2231744-29-7

Target & IC50

BTK: ic50 1nM (DC50)

In Vitro

MT-802 degrades BTK (DC50: 9.1nM). The maximal degradation being observed by 250nM.

Product Categories/Family for MT-802, inhibitor

Angiogenesis; Tyrosine Kinase/Adaptors

Product References and Citations for MT-802, inhibitor

Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry.2018 Jul 3;57(26):3564-3575.

Other Notes

Small volumes of MT-802, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MT-802 purchase

MBS5755235 is an inhibitor targeting MT-802.