Nitroflurbiprofen Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

361.36

<1mg/ml refers to the product slightly soluble or insoluble

C19H20FNO5

O=C(OCCCCO[N+]([O-])=O)C(C)C1=CC=C(C2=CC=CC=C2)C(F)=C1

158836-71-6

COX

Nitroflurbiprofen is a NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by decreasing intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to a vasoconstrictor. In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusions (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45mg/kg), Flurbiprofen (30mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements.

Immunology/Inflammation; Neuroscience