NS1652 Inhibitor

Name: NS1652 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755278
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755278

NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6uM in human and mouse red blood cells. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NS1652, Inhibitor

Full Product Name

NS1652

Product Gene Name

NS1652, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

324.25

Solubility

DMSO: 4.9mg/mL (15.11mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Boiling Point

355 degree C

Formula

C15H11F3N2O3

SMILES

OC(=O)c1ccccc1NC(=O)Nc1cccc(c1)C(F)(F)F

CAS Number

1566-81-0

Target & IC50

chloride channel, human and mouse red blood cell: ic50 1.6uM

In Vitro

In mice, NS1652 (50mg/kg, i.v.) blocks murine erythrocyte Cl- conductance by >90%[2].

Product Categories/Family for NS1652, inhibitor

Membrane transporter/Ion channel

Product References and Citations for NS1652, inhibitor

Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24.
Kjaer K, et al. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24.
Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS165Blood. 2000 Mar 1;95(5):1842-8.
Bennekou P, et al. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood. 2000 Mar 1;95(5):1842-8.

Other Notes

Small volumes of NS1652, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NS1652 purchase

MBS5755278 is an inhibitor targeting NS1652.