NSC781406 Inhibitor

Name: NSC781406 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755285
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755285

NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2nM for PI3Kalpha). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NSC781406, Inhibitor

Full Product Name

NSC781406

Product Gene Name

NSC781406, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

627.68

Solubility

DMSO: 150mg/mL (238.98mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C29H27F2N5O5S2

SMILES

FC1=CC(F)=CC=C1S(=O)(NC2=CC(C3=CC=C(N=CC=C4C#CCN5CCN(S(C)(=O)=O)CC5)C4=C3)=CN=C2OC)=O

CAS Number

1676893-24-5

Target & IC50

PI3Kalpha: ic50 2nM
PI3Kgamma: ic50 2.7nM
PI3Kbeta: ic50 9.4nM
PI3Kdelta: ic50 14nM
mTOR: ic50 5.4nM

In Vitro

NSC781406 is well tolerated at 30mg/kg, with no observed mortality or significant reduction of body weight. NSC781406(30mg/kg) treatment, causes statistically significant antitumor activity, in the xenograft models. It has a mean reduction in the relative tumor volume ratio of 52%. Sorafenib shows an inhibition ratio of 44% at 50mg/kg.

Product Categories/Family for NSC781406, inhibitor

PI3K/Akt/mTOR signaling

Product References and Citations for NSC781406, inhibitor

Chen Y, et al. Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma. Bioorg Med Chem. 2016 Mar 1;24(5):957-66.

Other Notes

Small volumes of NSC781406, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NSC781406 purchase

MBS5755285 is an inhibitor targeting NSC781406.