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NU6300 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755289

MBS5755289 is an inhibitor targeting NU6300. NU6300 is an inhibitor of the first covalent ATP-competitive CDK2. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NU6300, Inhibitor
Full Product Name
NU6300
Product Gene Name
NU6300, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
413.49
Solubility
DMSO: 32mg/mL (77.39mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C20H23N5O3S
SMILES
O=S(C(C=C1)=CC=C1NC2=NC(OCC3CCCCC3)=C4C(NC=N4)=N2)(C=C)=O
CAS Number
2070015-09-5
Target & IC50
CDK2: ic50 0.16uM
In Vitro
NU6300 blocks the inhibitor binding site. The effect was time-dependent and relatively slow, with less than 50% reduction of the apparent binding capacity in 20 hr. NU6300 is a covalent CDK2 inhibitor that illustrates the potential of using vinyl sulfones to mediate irreversible inhibition.

Product Categories/Family for NU6300, inhibitor

Microbiology&virology; Antifungal; Cell Cycle/Checkpoint

Structure of NU6300, inhibitor

NU6300 Inhibitor – Cat# MBS5755289

Product References and Citations for NU6300, inhibitor

Anscombe E, et al. Identification and Characterization of an Irreversible Inhibitor of CDKChem Biol. 2015 Sep 17;22(9):1159-1164.

Other Notes

Small volumes of NU6300, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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