ORG-12962 Inhibitor

Name: ORG-12962 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5755310
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755310

Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptors (pEC50s: 6.38 and 6.28, respectively). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Org-12962, Inhibitor

Full Product Name

Org-12962

Product Gene Name

Org-12962, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

265.66

Solubility

DMSO: 250mg/mL (941.05mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C10H11ClF3N3

SMILES

FC(F)(F)C1=C(N=C(C=C1)N2CCNCC2)Cl

CAS Number

132834-56-1

Target & IC50

5-HT2C Receptor: ic50 7.01 (pEC50)
5-HT2A Receptor: ic50 6.38 (pEC50)
5-HT2B Receptor: ic50 6.28 (pEC50)

In Vitro

Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%). Org-12962 (intraperitoneal injection; 0.3-3.2mg/kg) obviously enhances the postinjection frequency thresholds for self-interruption (F3.71=11.40) [1].

Product Categories/Family for Org-12962, inhibitor

GPCR/G Protein; 5-HT Receptor; Neuroscience

Product References and Citations for Org-12962, inhibitor

Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999 Sep;128(1):13-20.
Porter RH,et al. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol. 1999 Sep;128(1):13-20.
Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.
Jenck F, et al. Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.
Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.
Faassen F, et al. Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.

Other Notes

Small volumes of Org-12962, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Org-12962 purchase

MBS5755310 is an inhibitor targeting Org-12962.