GNE2861 Inhibitor – GNE 2861

Name: GNE2861 Inhibitor; GNE 2861; MyBioSource
Brand: MyBioSource
SKU: MBS5755328
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755328

GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GNE 2861 (GNE2861), Inhibitor

Full Product Name

GNE 2861

Product Gene Name

GNE2861, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

406.48

Solubility

DMSO: 270mg/mL (664.24mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C22H26N6O2

SMILES

OC1(C#CC2=CC=C3N=C(NCCOC)N(C4=NC(N)=NC=C4)C3=C2)CCCCC1

CAS Number

1394121-05-1

Target & IC50

PAK4: ic50 7.5nM
PAK5: ic50 36nM
PAK6: ic50 126nM

Product Categories/Family for GNE2861, inhibitor

Cytoskeletal Signaling; PAK

Product References and Citations for GNE2861, inhibitor

Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.
Karpov AS, et al. Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett. 2015 May 22;6(7):776-81.

Other Notes

Small volumes of GNE2861, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE2861 purchase

MBS5755328 is an inhibitor targeting GNE2861. Also known as GNE 2861.