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PAN-RAS-IN-1 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755330

Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pan-RAS-IN-1, Inhibitor
Full Product Name
Pan-RAS-IN-1
Product Gene Name
Pan-RAS-IN-1, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
717.65
Solubility
DMSO: 50mg/mL (69.67mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C36H41Cl2F3N6O2
SMILES
O=C(C1(N)CCNCC1)NCCCN2C3=CC=C(CN4CCN(CC5=C(Cl)C=CC=C5Cl)CC4)C=C3C(C6=CC=C(OC(F)(F)F)C=C6)=C2
CAS Number
1835283-94-7
Target & IC50
Others
In Vitro
Pan-RAS-IN-1-treated mice show decreased tumor pERK levels compared with vehicle-treated mice. Pan-RAS-IN-1 administration causes inhibition of tumor growth over 15 days of treatment, A modest increase in cleaved caspase-3 is also observed, showing that pan-RAS-IN-1 has the capacity to induce caspase activation in this model[1].

Structure of Pan-RAS-IN-1, inhibitor

PAN-RAS-IN-1 Inhibitor – Cat# MBS5755330

Product References and Citations for Pan-RAS-IN-1, inhibitor

Welsch ME, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017 Feb 23;168(5):878-889.e29.
Welsch ME, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 2017 Feb 23;168(5):878-889.e29.

Other Notes

Small volumes of Pan-RAS-IN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Pan-RAS-IN-1 purchase

MBS5755330 is an inhibitor targeting Pan-RAS-IN-1.
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