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PEAQXhydrate Inhibitor – PEAQX Tetrasodium Hydrate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5755340

PEAQX tetrasodium hydrate is an effective and orally activenMDA antagonist with a 15-fold preference for humannMDA receptors with the 1A/2A(IC50=270nM), rather than 1A/2B(29,600nM). More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PEAQX tetrasodium hydrate (PEAQXhydrate), Inhibitor
Full Product Name
PEAQX tetrasodium hydrate
Product Gene Name
PEAQXhydrate, inhibitor
Product Synonym Names
NVP-AAM077 tetrasodium hydrate
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
560.15
Solubility
H2O: 25.5mg/mL (45.52mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C17H15BrN3Na4O6P
SMILES
[O-]P([O-])(C(N[C@@H](C)C1=CC=C(Br)C=C1)C2=CC=CC3=C2N=C([O-])C([O-])=N3)=O.[H]O[H].[Na+].[Na+].[Na+].[Na+]
Target & IC50
Others
In Vitro
PEAQX is practically inactive in Xenopus oocytes expressing hNMDA 1A/2B receptors, displays an ED50 value of 23mg/kg in the MES test [1]. Sprague-Dawley rats were treated on PN7, PN9, and PN11 with PCP (10mg/kg), PEAQX (NR2A-preferring antagonist; 10, 20, or 40mg/kg), or ifenprodil (selective NR2B antagonist; 1, 5, or 10mg/kg) and sacrificed for measurement of caspase-3 activity (an index of apoptosis) or allowed to age and tested for locomotor sensitization to PCP challenge on PN28-PN35. PCP or PEAQX on PN7, PN9, and PN11 markedly elevated caspase-3 activity in the cortex; ifenprodil showed no effect. Striatal apoptosis was evident only after subchronic treatment with a high dose of PEAQX (20mg/kg). Animals treated with PCP or PEAQX on PN7, PN9, and PN11 showed a sensitized locomotor response to the PCP challenge on PN28-PN35 [2].

Structure of PEAQXhydrate, inhibitor

PEAQXhydrate Inhibitor – Cat# MBS5755340

Product References and Citations for PEAQXhydrate, inhibitor

Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitivenMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.
Auberson YP, et al. 5-Phosphonomethylquinoxalinediones as competitivenMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.
Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.
Anastasio NC, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.

Other Notes

Small volumes of PEAQXhydrate, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PEAQXhydrate purchase

MBS5755340 is an inhibitor targeting PEAQXhydrate. Also known as PEAQX tetrasodium hydrate.
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